Information from the abstract
Abstract While the use of gender-affirming hormone therapy is steadily increasing, safety data specific to Asian transgender populations remain limited. This study aimed to evaluate the changes in activated protein C resistance and global coagulation profiles following a short-term testosterone injection among Thai testosterone-naïve, transmasculine individuals. Participants were enrolled and received 150 mg of testosterone enanthate intramuscularly every 2 weeks for total 14 weeks. Blood samples were collected at baseline and week 13 (mid-interval) to assess median change in APC sensitivity ratio (APCsr), coagulation markers and natural anticoagulant levels, alongside hematological, biochemical, and hormonal assessments. A total 29 participants were recruited. Median APCsr remained unchanged (from 2.77 [interquartile range {IQR} 2.70–2.85] at baseline to 2.78 [IQR 2.67–2.85] at week 13 [p = 0.829]). The overall hemostatic shift was heterogeneous. Subgroup analysis according to total testosterone levels did not exhibit significant trend toward procoagulative change. APCsr did not significantly correlate with hormonal profiles. In predictive modeling, estradiol positively correlated with factor IX and fibrinogen levels, whereas rising hematocrit predicted natural anticoagulant levels. Short-term administration of testosterone enanthate did not alter the baseline risk of venous thromboembolism among Thai transmasculine population. Trial Registration: The Thai Clinical Trials Registry–TCTR20250826006.
Why this record is monitored
This record has an Impact Signal of 85/100 based on recency, source, collaboration, and bibliographic signals. It prioritizes monitoring and is not a judgment of research quality.
Related topics: Venous Thromboembolism Diagnosis and Management · Blood Coagulation and Thrombosis Mechanisms · Hormonal and reproductive studies
Thai researcher and institutional participation
Panachai Nimitpanya · Krasean Panyakhamlerd · Ammarin Suwan · Noppacharn Uaprasert · Punika Panichaya · Suchanant Chavaengkiat · Tassawan Rungruxsirivorn · Chulalongkorn University
Data limitations
This page is a bibliographic record based on abstract-level information, not a full analysis or quality assessment. Verify the DOI and original article before citation.