Ethanolic Leaf Extract of Annona muricata Pauses Plasmodium knowlesi Schizogony and Reduces Binding of Infected Red Blood Cells to Endothelial Cells
In vitro experiments evaluated ethanolic soursop-leaf extract against zoonotic Plasmodium knowlesi. The extract inhibited blood-stage development with a reported IC50 of 9.65 micrograms per milliliter and reduced binding of infected red blood cells to endothelial cells. The effect was parasitostatic rather than parasite-killing and is not evidence of efficacy in patients.
Thai researchersPolrat Wilairatana · Veeranoot Nissapatorn