THAI RESEARCH / GLOBAL SIGNAL

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3982ผลงานในฐานข้อมูล3461อ่านฉบับเต็มได้476สาขาวิจัย

EDITOR'S SIGNALRotating editor's selection

Evidence of global relevance

Characteristics, management, and outcomes of segmental and subsegmental pulmonary embolism in ICU patients: A retrospective cohort study

Researchers reviewed 896 CT pulmonary angiograms from 804 ICU patients between January 2019 and June 2025. Pulmonary embolism was identified in 164 examinations, while 104 patients had segmental or subsegmental embolism without a more proximal clot. Anticoagulation was given to 96% of this group and 86% of treated patients received therapeutic dosing. At 90 days, bleeding occurred in 15%, major bleeding in 12%, recurrent venous thromboembolism in 7.8% and mortality in 24%.

Nuanprae Kitisin · Nattaya Raykateeraroj · Sikarin UpalaSiriraj Hospital · Mahidol University

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In-depth research analyses

Source-verified editorial analyses, ordered by latest publication date

1,027 analyses

clinical-medicine76IMPACT SIGNAL

CXCR2 blockade potentiates HDAC3 deletion mediated antitumor immunity in colorectal cancer

HDAC3 is highly expressed in colorectal cancer (CRC) and associated with poor prognosis. This study reveals that HDAC3 deletion dually regulates chemokine expression through epigenetic mechanisms, promoting CD8⁺ T cell infiltration (via CXCL10) on one hand, while enhancing the recruitment of myeloid-derived suppressor cells (MDSCs) (via CXCL1/2/3/5) on the other. The latter, mediated through CXCR2 signaling, counteracts the intrinsic anti-tumor effect of HDAC3 deletion. We further demonstrate that combining a CXCR2 inhibitor effectively blocks MDSC infiltration and significantly enhances the immunotherapeutic efficacy mediated by HDAC3 deletion. This study systematically elucidates the "double-edged sword" role of HDAC3 in the CRC immune microenvironment and provides a theoretical and experimental basis for an HDAC3/CXCR2 dual-targeting therapeutic strategy.

Thai researchers

clinical-medicine76IMPACT SIGNAL

The Asia Pacific League of Associations for Rheumatology ( APLAR ) Consensus Statements for the Management of Reproductive Issues in Autoimmune Rheumatic Diseases

BACKGROUND: The management of reproductive health in individuals with autoimmune rheumatic diseases (AIRDs) has evolved into a primary clinical priority. Wide variations in clinical practice and drug availability in the Asia-Pacific regions necessitate localized frameworks. These consensus statements, developed by the Asia Pacific League of Associations for Rheumatology (APLAR) Special Interest Group for Women's Health & Reproductive Issues in Rheumatic and Musculoskeletal Diseases, aim to bridge the gaps within the region, foster multidisciplinary collaboration, and address regional knowledge deficits. METHODS: An expert panel comprising 16 members of the 13 APLAR member nation organizations formulated 23 research questions using the PICO framework. A systematic review of English-language literature up to July 2025 was conducted across the MEDLINE, Scopus, Google Scholar, and Cochrane Library databases, supplemented by a manual search of journals from the APLAR regions. Evidence from the APLAR region was appraised using the GRADE system. A modified Delphi online voting process was employed to reach consensus, pre-defined as ≥ 75% agreement. RESULTS: The panel approved four overarching principles and 86 statements, organized into 16 broad categories. These statements cover all three phases of pregnancy in AIRDs, the safety of medications during pregnancy and lactation, contraception, assisted reproductive techniques, fertility preservation, and hormonal replacement therapy, covering both female and male aspects as relevant. CONCLUSION: In a field often lacking high-quality data, these consensus statements from APLAR provide expert opinion-based guidance to support clinical decision-making. It is envisaged that it will assist in educational and training purposes and…

Thai researchers

public-health76IMPACT SIGNAL

GRB 241030A: A bright afterglow challenging forward shock emission

Context. Gamma-ray burst GRB 241030A ( z = 1.411) exhibited a particularly bright afterglow (similar to the ‘BOAT’, GRB 221009A), detected across gamma-ray, X-ray, UV, and optical bands. The extensive, multi-wavelength observations of this remarkable event provide a valuable opportunity to advance our understanding of GRB afterglow physics. Aims. We aim to constrain the physical properties of the jet, its microphysics, and the characteristics of the circumburst environment in the context of forward-shock emission. Methods. We compiled multi-wavelength observations spanning from a minute to a week after the prompt emission, processing the data through a unified photometry pipeline. Leveraging this comprehensive dataset, we analysed the observations both analytically and using Bayesian inference with two independent models. Our models assume that the afterglow emission arises from the strong forward shock of a laterally structured jet, with possible contributions from synchrotron self-Compton (SSC) scatterings. Results. We find that our models do reproduce the afterglow observations accurately, from the X-rays to the optical, favouring a jet propagating into a constant-density interstellar medium, with a viewing angle within the jet core. However, both analyses – with and without the inclusion of SSC scatterings – require parameter values that are extreme compared to expectations from standard theory. In particular, our results imply extremely energetic jets despite regular prompt energy, leading to a very inefficient prompt emission. Furthermore, the jets are particularly inefficient at accelerating particles, with low ϵ e and ϵ B , leading to significant SSC emission. Finally, our analyses indicate that the jets have large opening angles and propagate in high-density…

Thai researchers

multidisciplinary75IMPACT SIGNAL

Pioneering plant virology research for a healthier future: a summary of the 2025 American Society for Virology (ASV) Plant Virology Satellite Symposium

The American Society for Virology (ASV) 2025 Annual Meeting, held from 14 to 17 July at the Palais des congrès de Montréal and hosted by McGill University, featured a dedicated Plant Virology Satellite Symposium entitled "Pioneering Plant Virology Research for a Healthier Future." This symposium emphasized the inclusion of topics of significance to early-career scientists. The program highlighted advances across diverse areas of plant virology, including mechanisms of transgenerational virus transmission, the economic and biological impacts of grapevine viruses on viticulture, emerging plant virus vectors, and innovative applications of plant viruses as nanomaterials for cancer immunotherapy. Additionally, emerging research on small functional proteins encoded by plant viruses and plant defense mechanisms underscored the complexity of viral genomes and host interactions. The symposium showcased cutting-edge approaches and strategies aimed at addressing global challenges in plant health and food security.

Thai researchers

clinical-medicine75IMPACT SIGNAL

Global disparities in hearing care services and infrastructure: findings from a 47-country international provider survey

OBJECTIVE: Access to audiological services and support for individuals with hearing loss varies widely across low- and middle- income countries (LMICs) and high-income countries (HICs). This study examines disparities in the availability of audiological services across World Bank income groups. DESIGN: An international cross-sectional survey was developed and distributed by the Global Otolaryngology Head and Neck Surgery Initiative. The survey evaluated the availability of audiology and support services across countries. Multiple responses from one country were combined into one entry. Statistical significance between groups was assessed using chi-squared tests.Study Sample: A total of 135 responses were received from 47 countries (30 LMICs and 17 HICs). RESULTS: Significant disparities were identified across most service categories. HICs reported greater availability of newborn hearing screening, diagnostic tests, paediatric and adult hearing assessments, vestibular services, and hearing technologies compared to LMICs. Advanced diagnostic tools and hearing devices such as cochlear implants were significantly more accessible in HICs. CONCLUSIONS: Substantial differences were observed in audiological and rehabilitative services across HICs and LMICs. Efforts to bridge significant gaps are essential for achieving equitable hearing health care worldwide.

Thai researchers

clinical-medicine75IMPACT SIGNAL

Stapokibart provides significant improvements in signs and symptoms of atopic dermatitis irrespective of prior systemic treatment: a post-hoc analysis of a phase 3 trial

Objectives This post-hoc analysis of CM310AD005 conductedaimed to analyze the efficacy and safety of stapokibart in adults with moderate-to-severe atopic dermatitis (AD) with and without prior systemic treatment.Methods In CM310AD005, eligible patients were randomized 1:1 to receive stapokibart 600 (loading dose)-300 mg and placebo Q2W for 16 weeks; all patients subsequently received stapokibart 300 mg Q2W for 36 weeks.Results At week 16, in systemic treatment-naïve patients, stapokibart led to significantly higher response rates than placebo for ≥75% improvement from baseline in the Eczema Area and Severity Index score (EASI-75, 70.3% vs. 29.1%), EASI-90 (38.1% vs. 13.3%), Investigator’s Global Assessment score of 0 or 1 (45.2% vs. 19.4%), and ≥4-point reduction in weekly average of daily Peak Pruritus Numerical Rating Scale score (34.8% vs. 13.9%) (all p < 0.0001). Among patients with prior systemic treatment, these response rates were also significantly higher in the stapokibart group, reaching 61.5% vs. 19.3%, 35.4% vs. 7.2%, 42.7% vs. 9.6%, and 37.5% vs. 7.2% (all p < 0.0001), respectively. All patients showed further improvements through week 52. The most common treatment-emergent adverse events were infections and infestations, occurring in 61.6% and 70.5% of patients with and without prior systemic treatment.Conclusions Stapokibart demonstrated significant clinical efficacy and manageable safety in AD patients irrespective of prior systemic treatment.

Thai researchers

clinical-medicine75IMPACT SIGNAL

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Cytochrome P450 2D6 (CYP2D6)-mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor-positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype-phenotype correlation. To address these gaps, long-read Oxford Nanopore sequencing was applied to resolve CYP2D6 structural complexity and evaluate its impact on endoxifen metabolism. The study cohort included 492 Thai breast cancer patients, with multivariable analysis performed on 361 individuals receiving standard-dose tamoxifen to determine the association between CYP2D6 activity scores and plasma endoxifen concentrations. Long-read sequencing identified 82 distinct diplotypes and successfully resolved complex structural variations, including the prevalent CYP2D6*36 + *10 non-identical duplication. Overall, 46.55% of patients were classified as having decreased enzyme function, primarily intermediate metabolizers (45.53%). CYP2D6 activity score emerged as the strongest determinant of endoxifen exposure (P < 0.001). Decreased-function genotypes were significantly associated with lower endoxifen levels (using an exploratory benchmark of ≤5.97 ng/mL), independent of parent drug concentration. These findings demonstrate that long-read sequencing enables the precise resolution of CYP2D6 structural complexity. By accurately capturing rare and complex CYP2D6 alleles, the results indicate that standard genotyping may misclassify certain patients, potentially placing a large portion of the studied population at an unrecognized risk of low tamoxifen exposure.

Thai researchers

clinical-medicine75IMPACT SIGNAL

Membranous remodeling of basal infoldings in attenuated epithelial cells of dilated renal tubules under unilateral ureteral obstruction (UUO) in adult mouse kidney.

Under unilateral ureteral obstruction (UUO) in mouse kidneys, comparing proximal and distal tubules and collecting ducts, the distal tubules exhibited the most pronounced dilation and epithelial attenuation. Basal infoldings, typically well-developed in normal distal tubule cells, were infrequently present. Instead, the cell base was predominantly covered by flat-contoured plasma membranes interspersed with clusters of palisade-aligned thin cytoplasmic processes. These processes resembled the mitochondria-free terminal portions of cytoplasmic processes normally enclosed by basal infolding membranes in normal distal tubule cells. Some process clusters were enclosed by internal extensions of adjacent flat-contoured membranes, forming process-containing membranous sacs partially open to the basal interstitial space. Similar membranous bodies were observed deep within the cells, with some opening to intercellular spaces through fusion with lateral cell membranes. These membrane modifications likely represent the morphological sequence of membrane dynamics, providing additional membranes to compensate for the increased basal surface area in dilated tubules. Similarly, the collecting ducts dilated with attenuated epithelia and the basal surfaces were covered by flat-contoured plasma membranes with sparse clusters of palisade-aligned processes, suggesting basal infoldings, which also serve as a membrane supply to basolateral surfaces in these cells. However, membranous sacs containing thin processes were less frequent in collecting duct cells, indicating a less extensive membrane remodeling process compared with distal tubule cells. On the other hand, the proximal tubules exhibited the lowest luminal dilation and epithelial attenuation, and the replacement of the diminished…

Thai researchers

multidisciplinary75IMPACT SIGNAL

Constitutive DUSP2 expression enhances lymphoid cell proliferation by activating CDK1 and promotes lymphomagenesis

DUSP2 is known as a nuclear dual-specificity phosphatase, highly restricted to immune cells. Its expression is induced by antigenic and mitogenic stimuli and has been implicated in immune cell differentiation and functions. However, its role in immune cell mitotic proliferation and hematologic malignancies has not been rigorously examined. Here, we show DUSP2 is highly expressed in human B-cell, T cell, and other hematologic malignancies. Ablating DUSP2 expression in lymphoma cell lines decreases growth and viability. In mice, transgenic Dusp2 expression promotes B-cell and T cell proliferation, and malignant transformation. Mechanistically, DUSP2 promotes cell cycle progression by activating CDK1 through dephosphorylation at inhibitory Tyr15 and Thr14, which is mediated not by its own phosphatase activity, but instead by a structural motif that recruits CDC25 phosphatases. This work reveals an unexpected oncogenic role for DUSP2 in lymphoid malignancies and the function of a structural motif, which represents an appealing target site for therapeutic intervention.

Thai researchers

energy-materials75IMPACT SIGNAL

Influence of Alloy and Alloy Composition on Dendrite Formation and Electrochemical Performance in Aluminum Metal Batteries

Interfacial instability and sluggish kinetics of high-purity aluminum (Al) anodes remain major bottlenecks for rechargeable nonaqueous aluminum-ion batteries (AIBs) to achieve high electrochemical performance. This study systematically evaluates the effects of alloying compositions on dendrite formation in commercial AA1235, AA3003, and AA8006 Al alloys as scalable, high-performance and low-cost anodes in chloroaluminate-based electrolyte AIBs. Comprehensive results demonstrate that the commercial Al alloys achieve superior cycling stability over pure Al metal benefited by leveraging a balanced intermetallic distribution that promotes uniform Al plating and suppresses vertical dendrite propagation. In contrast, high-purity Al exhibits limited long-life cycles due to its inhomogeneous native oxides. Our findings reveal that tailored commercial alloys can outperform their high-purity materials, offering a strategic pathway for durable and cost-effective energy storage based on multivalent metal-ion chemistries.

Thai researchers

clinical-medicine75IMPACT SIGNAL

Adolescent sexual and reproductive health assessment in clinical practice in India: a qualitative study triangulating clinician practices and young adults’ experiences

OBJECTIVES: To characterise current practices in adolescent sexual and reproductive health (SRH) assessment during routine clinical encounters in a tertiary care setting and to triangulate these findings with young adults' experiences of adolescent healthcare, identifying gaps between recommended assessment approaches and real-world clinical practice. DESIGN: Qualitative study using semistructured in-depth interviews (IDIs) and group discussions with clinicians, followed by a sequential triangulation phase involving IDIs with young adults. Data were analysed using Braun and Clarke's reflexive thematic analysis. SETTING: A tertiary care hospital in South Karnataka, India. PARTICIPANTS: 33 clinicians across six departments participated in four IDIs and five group discussions (focus-group or small-group discussions). 10 undergraduate young adults were recruited for IDIs in the triangulation phase. Sampling was guided by the information power principle. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Current patterns and practices of SRH assessment, perceived barriers and challenges and concordance between clinician-reported practices and young adults' experiences of care. RESULTS: Three domains emerged: current assessment practices, contextual challenges and improvement strategies. SRH assessment was largely symptom-driven and reactive rather than routinely integrated into consultations. Clinicians described practices shaped by sociocultural stigma, parental presence, privacy limitations and medicolegal uncertainty. In response, many relied on informal strategies such as rapport-building, indirect questioning or referral pathways. Triangulation with young adults' experiences confirmed the reactive nature of SRH enquiry, but revealed critical mismatches: young adults…

Thai researchers

multidisciplinary74IMPACT SIGNAL

Correction: Enhancing Geomorphological Mapping in Northern Thailand Using Convolutional Neural Networks

ระเบียนนี้เป็นประกาศแก้ไขของบทความเดิมเรื่องการใช้โครงข่ายประสาทแบบคอนโวลูชันทำแผนที่ธรณีสัณฐานในภาคเหนือของไทย ไม่ใช่งานวิจัยฉบับใหม่ และแหล่งข้อมูลที่ระบบเข้าถึงไม่มีข้อความอธิบายว่ามีการแก้ไขส่วนใด จึงไม่ควรนับเป็นหลักฐานหรือผลงานใหม่แยกจากบทความต้นฉบับ ผู้อ่านควรเปิด DOI เพื่อตรวจรายการแก้ไขและอ่านควบคู่กับฉบับเดิม

Thai researchers

BIBLIOGRAPHIC RESEARCH WATCHLIST

Bibliographic research records

Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.

2,955records

2,955 records

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Tourist perceptions and service design for sustainable community forests

Humanities, Arts and Social Sciences Studies

Thailand-affiliated authors: Sakol Teeravarunyou · Pongsak Kitirojpan · Kochahem Kamolwit · Pavinee Patanachan
Institutions: King Mongkut's University of Technology Thonburi

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Psychometric Evaluation of the Thai Version of the Debriefing Experience Scale among Nursing Students: A Cross-Sectional Study

Pacific Rim International Journal of Nursing Research

Thailand-affiliated authors: Onouma Thummapol · Thitaporn Wilson · Werayuth Srithumsuk · Jitrada Pongtharatikd
Institutions: Assumption University · Royal Thai Army Nursing College · Phetchaburi Rajabhat University · Phetchabun Rajabhat University

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Adolescents with chronic illnesses: discovering eating disorder susceptibility and risk factors

International Journal of Adolescence and Youth

Thailand-affiliated authors: Sasinan Noonpradej · Supinya In‐iw · Gornmigar Sanpawitayakul · Supparat Theppiban · Suppanut Charoenjit · Boonying Manaboriboon
Institutions: Siriraj Hospital · Mahidol University

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

The Influence of Affiliate Marketing Content on Online Purchase Decisions via Consumer Attitudes: Empirical Evidence from Shopee and Lazada Platforms

WSEAS TRANSACTIONS ON BUSINESS AND ECONOMICS

Thailand-affiliated authors: Suchanya Saichana · Benjarut Chaimankong · Wirunpatch Boonsongprasert · Suvikrom Mapraneat
Institutions: Kasetsart University

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Implementing a seven-color NCD risk screening system across 39 academic health institutions in Thailand using the consolidated framework for implementation research

Discover Public Health

Thailand-affiliated authors: Chaweewan Sridawruang · Atcharawadee Sriyasak · Pennapa Sriring · Vichai Tienthavorn · Wuttikul Thanakanjanaphakdee · Ratdawan Klungklang · Atiya Sarakshetrin · Chiraporn Worawong · Penphan Pitaksongkram · Wanida Sripromsa · Pornpun Manasatchakun · Buppha Raksanam · Benjaporn Rajataramya
Institutions: Praboromarajchanok Institute Ministry of Public Health · Boromarajonani College of Nursing, Khon Kaen · Boromarajonani College of Nursing, Yala · Ministry of Public Health · Sirindhorn College of Public Health, Khon Kaen · Boromarajonani College of Nursing, Udon Thani · Boromarajonani College of Nursing · Sirindhorn College of Public Health, Trang

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Integrating participatory ecosystem service valuation and community perspectives for Thale Noi Wetland conservation

Social Sciences & Humanities Open

Thailand-affiliated authors: Sitthinan Wiwatthanapornchai · Payomporn Raksachon · Mantana Daengphet · Buppachat Taengkliang · Timpika Taojoo · Sopispilai Thongsai · Saichai Kaew-On
Institutions: Sakon Nakhon Rajabhat University · Rajamangala University of Technology Srivijaya

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Green Finance, Stage of Economic Development, and Low-Carbon Transition: Evidence from Dynamic Panel and Threshold Regression Models Using Chinese Prefecture-Level-City Data

Sustainability

Thailand-affiliated authors: Yanqin Xu · Monchaya Chiangpradit · Piyapatr Busababodhin
Institutions: Mahasarakham University

85IMPACT SIGNAL

Multidisciplinary28 Sep 2026

Evaluating competency-based education: divergence in implementation challenges among primary school English teachers in Thailand’s Deep South

Current Issues in Language Planning

Thailand-affiliated authors: Athip Thumvichit · Benjawan Tejasen · Rusdee Masor · Uniansasmita Samoh
Institutions: Mahidol University · Prince of Songkla University

85IMPACT SIGNAL

Multidisciplinary27 Sep 2026

Conceptualizing cultural adaptation through game-based learning among international students: evidence from a systematic scoping review

International Journal of Evaluation and Research in Education (IJERE)

Thailand-affiliated authors: Yoon Shwe Sin · Ophat Kaosaiyaporn · Warapark Maitreephun
Institutions: Prince of Songkla University

85IMPACT SIGNAL

Multidisciplinary27 Sep 2026

Psychometric properties of the Thai version of the Interpersonal Rejection Sensitivity Scale (IRSS-Thai) among Thai secondary school students

Journal of Mental Health of Thailand - วารสารสุขภาพจิต แห่งประเทศไทย

Thailand-affiliated authors: Supawadee Charoenwanit · Tipsuda Sumneangsanor · Sukanya Phoolphoklang · Prakaipetch Winaiprasert
Institutions: Thammasat University

85IMPACT SIGNAL

Multidisciplinary27 Sep 2026

Natural deep eutectic solvents for sustainable bioactive compound extraction: Fundamentals, emerging technologies, current scale-up challenges, and future industrial perspectives

Advances in Sample Preparation

Thailand-affiliated authors: Hla Myo · Desy Liana · Anuchit Phanumartwiwath
Institutions: Chulalongkorn University

85IMPACT SIGNAL

Multidisciplinary27 Sep 2026

The STUDIES model: validating a human-centric framework for Education 5.0

International Journal of Evaluation and Research in Education (IJERE)

Thailand-affiliated authors: Phichittra Thongpanit · Pratya Thongpanit · Sutep Uamcharoen
Institutions: Nakhon Phanom University · Walailak University

85IMPACT SIGNAL

Multidisciplinary27 Sep 2026