Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection
Two randomized controlled phase 3 trials are investigating the antisense oligonucleotide drug bepirovirsen in patients with chronic hepatitis B. with researchers from Chiang Mai University co-authoring
A post hoc analysis of the DEN-301 placebo arm followed 30,620.6 person-years, identifying 560 virologically confirmed dengue cases among 9,698 febrile illnesses; 142 cases, or 25.4%, were hospitalized.
A 20-year-old man on automated peritoneal dialysis developed vague abdominal symptoms, weight loss and declining ultrafiltration. Repeated dialysate cultures, acid-fast staining and molecular tests were negative despite mononuclear-predominant leukocytosis. Contrast CT identified peritoneal nodules, CT peritoneography showed a trapped dialysate pocket, and targeted biopsy demonstrated necrotising granulomatous inflammation. Tissue culture grew M. kansasii resistant to rifampicin, moxifloxacin and ciprofloxacin.
HITAP reviewed 278 HTA capacity-strengthening activities in 25 countries from 2010 to mid-2025. Asia accounted for 151 activities and 128 engagements were programmatic rather than ad hoc. Knowledge sharing represented 26% and research or project collaboration 21%. Among 11 African partner countries, only three had programmatic engagement, accounting for 30 activities.
Morphology combined with ITS, LSU, rpb2 and β-tub phylogenies distinguished Nigropunctata pseudohydei as a new species and confirmed the first Thai record of N. complanata.
Thai researchersZaw Lin Tun · Digvijayini Bundhun · Kevin D. Hyde
An eight-country perspective argues that telemedicine, wearables and home sensors, augmented AI and mobile health can distribute expertise, observe symptoms between visits and support self-management, particularly where neurologists are scarce. Impact depends on infrastructure, interoperability, workforce, governance and equity-first hybrid care, not devices alone.
DJC6219 and NK62157 were isolated from municipal wastewater and characterised through host-range assays, electron microscopy, stability, multiplicity-of-infection optimisation, growth kinetics and genomics.
The authors review challenges in estimating preventable AMR burden and advocate explicit counterfactuals, confounding control and principled combination of individual studies.
Thai researchersCherry Lim · Sue J. Lee · Yin Mo · Ben S. Cooper
Ten Asia-Pacific experts developed 11 consensus statements on mild traumatic brain injury and use of GFAP/UCH-L1 within 12 hours. Final agreement was 90-100%, emphasizing biomarkers as adjuncts while clinical assessment and locally available imaging remain central.
RGD-functionalized cannabidiol lipid nanoparticles increased cellular uptake threefold and in-vitro BBB transport by 65%, while reducing inflammatory and oxidative markers. In a preclinical Alzheimer's model, cognition, Aβ/tau pathology, metabolism and gut-barrier indicators improved. The findings are promising but not evidence in patients.
Researchers used the UNDRR Stop Disasters online game with students, water professionals and community members in Thailand and Malaysia. A post-game survey of 35 participants found high enjoyment, lively interaction and perceived reinforcement of declarative flood-management knowledge.
Among 1,870 critically ill patients with acute kidney injury, sodium and potassium from arterial blood-gas analysers showed relatively good agreement with central laboratory values, with potassium having the narrowest limits. Clinically meaningful discrepancies occurred in 7.0% of sodium, 14.1% of potassium and 31.4% of chloride measurements, so rapid bedside results should support rather than replace reference testing.
This multicentre secondary analysis used the validated 2018–2020 TH-SOSGOQ 2.0 database. The full cohort included 68 patients and the reliability/construct-validity cohort 64. Mean age was 57 years and 55.9% were women. Internal consistency was 0.832 and test-retest ICCs ranged from 0.52 to 0.85.
Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.
3,510records
3,510 records
70IMPACT SIGNAL
Global Public Health
Isolate-Specific Modulation of Growth, Carbon Allocation, and Transcriptomic Responses in Spirodela polyrhiza by Duckweed-Associated Bacteria
Microorganisms
Thailand-affiliated authors
Arinthip Thamchaipenet · Masaaki Morikawa
Institutions
Kasetsart University
70IMPACT SIGNAL
Multidisciplinary
Comparative Dermatological Bioactivities of Chlorophylized and Dechlorophylized Centella asiatica Extracts
Evaluation of Inhibitory Activities of Phenolic and Flavonoid Constituents of Nelumbo nucifera Gaertn. Against Tyrosinase, Elastase, and Collagenase by Computational Methods and Supported by Experimental Validation
Numerical Analysis of First- and Second-Law Performance in Round Tubes Equipped with Multiple Helical Screw Tape Inserts
Eng—Advances in Engineering
Thailand-affiliated authors
Smith Eiamsa‐ard · Sathaporn Liengsirikul · S. Chokphoemphun · Varesa Chuwattanakul · Paisan Naphon · Monsak Pimsarn
Institutions
Mahanakorn University of Technology · Kasetsart University · Sakon Nakhon Rajabhat University · King Mongkut's Institute of Technology Ladkrabang · Srinakharinwirot University
70IMPACT SIGNAL
Global Public Health
Maternal ontogeny modulates auxin-associated cutting mortality in Amentotaxus formosana, with genotype-specific responses revealed by Cox proportional hazards modelling
Frontiers in Plant Science
Thailand-affiliated authors
Meng‐Shin Shiao
Institutions
Ramathibodi Hospital
70IMPACT SIGNAL
Clinical Medicine
Spatial Determinants of Pathogenic Leptospira Viability in Paddy Field Surface Waters: Mechanistic Insights from Machine Learning and Geographically Weighted Logistic Regression
Depressive Symptoms Among Orphaned University Students in Thailand: The Role of Attachment Insecurity, Resilience, Inner Strength, and Perceived Social Support