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EDITOR'S SIGNALRotating editor's selection

Province-scale real-world programme evidence

Phetchabun Screens 97.3% for HCV; 96.4% of SVR12-Evaluable Patients Are Cured, but Transmission Elimination Is Unproven

Phetchabun’s micro-elimination programme linked fingerstick anti-HCV testing, HCV-RNA confirmation, and 12-week sofosbuvir/velpatasvir treatment through primary-care and district-hospital services across all 11 districts under universal health coverage. From 2020 to April 2026, 389,547 of 400,567 targeted people were screened (97.25%); 14,845 of 18,340 anti-HCV-reactive participants received RNA confirmation (80.94%), identifying 10,996 active infections. Of 8,961 treatment-eligible patients, 8,842 received therapy (98.67%); among 6,719 evaluated at SVR12, 6,474 were cured (96.35%). The programme demonstrates province-scale test-to-treat feasibility, but not yet the incidence or mortality reductions required for elimination.

Wijitra Phaengkha · Pornjarim Nilyanimit · Nungruthai Suntronwong · Jiratchaya Puenpa · Duong Hoang Huy Le · Saranya Ngamnimit · Pattama Janpathip · Lapasrada Kamput · Kawin Thongnoi · Wanalee Toomta · Phatcha Wohanklong · Jarunlak Saokeaw · Niphapornt Thammajit · Suwannee Rerngleum · Ananyalak Yoisara · Nitiya Srisuk · Jidapa Suwannachat · Anchalee Karagate · Rujipat Wasitthankasem · Yong PoovorawanNam Nao Hospital, Phetchabun · Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University · Phetchabun Provincial Public Health Office · Phetchabun Hospital · Buengsamphan Hospital · Lomsak Hospital · Chondaen Hospital · Si Thep Hospital · Wang Pong Hospital · Wichianburi Hospital · Lomkao Crown Prince Hospital · Nongphai Hospital · Khao Kho Hospital · National Center for Genetic Engineering and Biotechnology, NSTDA · The Royal Society of Thailand

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Health sciences71IMPACT SIGNAL

Global potential16 Jul 2026

Gut microbiome modulation by Veillonella ratti induces resistance to EAE pathogenesis via microbe-derived metabolites

In a mouse experimental autoimmune encephalomyelitis model, infant-derived Veillonella ratti MHL0042 reshaped gut microbiota, reduced CD4+ IFN-gamma T cells and lowered activated spinal-cord microglia. The proposed mechanism involves depletion of pldA-containing bacteria and increased dioleoyl phosphatidylethanolamine (DOPE) in the gut, circulation and central nervous system. Exogenous DOPE reproduced attenuation of disease and microglial activation.

Thai researchersPanida Sittipo

Agricultural-Waste Biocomposites71IMPACT SIGNAL

Global potential16 Jul 2026

Processing-dependent reinforcing behavior of garlic peel and pineapple leaf fibers in poly(butylene succinate) all-biocomposites

Poly(butylene succinate) composites containing 10 or 20 wt% garlic-peel or pineapple-leaf fiber were milled and compression-molded at 120 or 150 C. Pineapple fiber retained a higher effective aspect ratio, but this did not translate proportionally into flexural improvement. Flexural behavior depended strongly on orientation and molding temperature, favoring longitudinal specimens and 120 C, while impact behavior followed different trends.

Thai researchersSupapit Patomnupong · Taweechai Amornsakchai · Ittipol Jangchud

Health sciences71IMPACT SIGNAL

Global potential16 Jul 2026

Antifungal susceptibility profiles of clinical and environmental Scedosporium and Lomentospora isolates from Taiwan: focus on olorofim activity and phylogenetic heterogeneity

CLSI M38-A3 testing covered 216 Taiwanese clinical and environmental isolates: 205 Scedosporium and 11 Lomentospora prolificans. L. prolificans was pan-resistant to tested agents except olorofim, while olorofim had MIC90 values at or below 0.12 mg/L across taxa. Most MIC variability, 72.5-89.2%, occurred within rather than between species, limiting species identity as a susceptibility proxy and supporting isolate-level testing.

Thai researchersPassanesh Sukphopetch

Functional Beverages and Microbiota70IMPACT SIGNAL

Global potential16 Jul 2026

Exploring the antioxidant and prebiotic potential of fermented Thai jasmine rice beverage: An in vitro study

Thai KDML 105 jasmine-rice amazake was compared with unfermented rice and Japanese amazake. Fermentation increased phenolic content over unfermented rice. DPPH inhibition was 70.34% for the Thai beverage versus 65.71% for Japanese amazake, while ABTS inhibition was lower (53.57% versus 95.42%). Lactobacillus plantarum grew well and exceeded the IMO reference, whereas E. coli growth did not differ. These are in vitro functional signals, not demonstrated human prebiotic benefits.

Thai researchersRan Kitkangplu · Krongpong Monpengpinij · Woottichai Nachaiwieng · Niwed Kullawong

Graphene Quantum Dots in Cement77IMPACT SIGNAL