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EDITOR'S SIGNALRotating editor's selection

Stepped-Wedge Cluster Randomized Trial

A Smartphone Antimicrobial Prescribing App Did Not Outperform Paper Guidelines Across Six Lao Hospitals

Across a stepped-wedge cluster randomized trial in six Lao hospitals, a smartphone version of national antimicrobial prescribing guidelines plus one stewardship training session did not significantly improve adherence over paper versions after adjustment for time, clustering, and confounders. Inpatient adherence was 25.6% versus 17.0% before adjustment, but the adjusted odds ratio was 1.26 (95% CI 0.8–1.9; p=0.276); outpatient results were also null. The finding argues for sustained, multifaceted stewardship rather than guideline access alone.

Sue J. Lee · Mavuto Mukaka · Nicholas P. J. Day · Paul N. NewtonMahidol University · Mahidol Oxford Tropical Medicine Research Unit (MORU)

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1,027 analyses

Catalysis and Biomass Chemistry72IMPACT SIGNAL

Global potential16 Jul 2026

Tuning Metal–Acid Cooperativity of Beta Zeolite-Supported Pt Catalysts for Selective Hydrogenolysis of 5-Hydroxymethylfurfural to Methyl Levulinate

By tuning Si/Al ratio and Pt loading in beta-zeolite-supported catalysts, the study balanced Brønsted/Lewis acidity and metal-support interactions. The optimized 0.5Pt/BEA-12.5 used Lewis sites to activate carbonyl intermediates and moderated Brønsted acidity to promote esterification without excessive humin. It achieved over 99% HMF conversion and 92.0% methyl-levulinate yield at low Pt loading and also processed glucose, fructose and sucrose feedstocks.

Thai researchersNuttapat Thiensuwan · Hannarong Pitayachinchot · Chawalit Ngamcharussrivichai

Fermentation and Sensory Science71IMPACT SIGNAL

Global potential16 Jul 2026

Mixed Fermentation of Non-Saccharomyces Yeast and Lactic Acid Bacteria Enhances Aroma Complexity and Sensory Quality of Kyoho Wine

Sequential Hanseniaspora opuntiae plus Saccharomyces cerevisiae fermentation was combined with simultaneous or sequential malolactic fermentation using Lactoplantibacillus plantarum. The mixed yeast system increased total esters 4.21-fold over the S. cerevisiae control. Simultaneous MLF produced more ethyl lactate, diethyl succinate and diacetyl, reaching 267.38 mg/L total esters and the highest acceptance score, 7.63/9, associated with floral, blackberry and creamy notes.

Thai researchersSaeid Jafari

Health sciences71IMPACT SIGNAL

Global potential16 Jul 2026

Gut microbiome modulation by Veillonella ratti induces resistance to EAE pathogenesis via microbe-derived metabolites

In a mouse experimental autoimmune encephalomyelitis model, infant-derived Veillonella ratti MHL0042 reshaped gut microbiota, reduced CD4+ IFN-gamma T cells and lowered activated spinal-cord microglia. The proposed mechanism involves depletion of pldA-containing bacteria and increased dioleoyl phosphatidylethanolamine (DOPE) in the gut, circulation and central nervous system. Exogenous DOPE reproduced attenuation of disease and microglial activation.

Thai researchersPanida Sittipo

Agricultural-Waste Biocomposites71IMPACT SIGNAL

Global potential16 Jul 2026

Processing-dependent reinforcing behavior of garlic peel and pineapple leaf fibers in poly(butylene succinate) all-biocomposites

Poly(butylene succinate) composites containing 10 or 20 wt% garlic-peel or pineapple-leaf fiber were milled and compression-molded at 120 or 150 C. Pineapple fiber retained a higher effective aspect ratio, but this did not translate proportionally into flexural improvement. Flexural behavior depended strongly on orientation and molding temperature, favoring longitudinal specimens and 120 C, while impact behavior followed different trends.

Thai researchersSupapit Patomnupong · Taweechai Amornsakchai · Ittipol Jangchud

Health sciences71IMPACT SIGNAL

Global potential16 Jul 2026

Antifungal susceptibility profiles of clinical and environmental Scedosporium and Lomentospora isolates from Taiwan: focus on olorofim activity and phylogenetic heterogeneity

CLSI M38-A3 testing covered 216 Taiwanese clinical and environmental isolates: 205 Scedosporium and 11 Lomentospora prolificans. L. prolificans was pan-resistant to tested agents except olorofim, while olorofim had MIC90 values at or below 0.12 mg/L across taxa. Most MIC variability, 72.5-89.2%, occurred within rather than between species, limiting species identity as a susceptibility proxy and supporting isolate-level testing.

Thai researchersPassanesh Sukphopetch

Functional Beverages and Microbiota70IMPACT SIGNAL

Global potential16 Jul 2026

Exploring the antioxidant and prebiotic potential of fermented Thai jasmine rice beverage: An in vitro study

Thai KDML 105 jasmine-rice amazake was compared with unfermented rice and Japanese amazake. Fermentation increased phenolic content over unfermented rice. DPPH inhibition was 70.34% for the Thai beverage versus 65.71% for Japanese amazake, while ABTS inhibition was lower (53.57% versus 95.42%). Lactobacillus plantarum grew well and exceeded the IMO reference, whereas E. coli growth did not differ. These are in vitro functional signals, not demonstrated human prebiotic benefits.

Thai researchersRan Kitkangplu · Krongpong Monpengpinij · Woottichai Nachaiwieng · Niwed Kullawong

Graphene Quantum Dots in Cement77IMPACT SIGNAL