A Smartphone Antimicrobial Prescribing App Did Not Outperform Paper Guidelines Across Six Lao Hospitals
Across a stepped-wedge cluster randomized trial in six Lao hospitals, a smartphone version of national antimicrobial prescribing guidelines plus one stewardship training session did not significantly improve adherence over paper versions after adjustment for time, clustering, and confounders. Inpatient adherence was 25.6% versus 17.0% before adjustment, but the adjusted odds ratio was 1.26 (95% CI 0.8–1.9; p=0.276); outpatient results were also null. The finding argues for sustained, multifaceted stewardship rather than guideline access alone.
Sue J. Lee · Mavuto Mukaka · Nicholas P. J. Day · Paul N. NewtonMahidol University · Mahidol Oxford Tropical Medicine Research Unit (MORU)
Paired samples from treatment-naïve gastric-cancer patients and controls showed substantially higher richness and diversity with mucosal brushing than biopsy. Brushing detected lower diversity and altered composition in cancer, whereas biopsy did not. Sampling method shapes microbiome signals, but causation and diagnostic utility are unproven.
Gizzard lesions in Thai chickens contained intranuclear inclusions, in-situ hybridization signal and PCR-confirmed fowl adenovirus. Hexon and fibre sequencing identified FAdV-8a strain FAdV8a_NPT_KU001_25, closer to a gizzard-tropic than an inclusion-body-hepatitis strain. Association is supported, but causation remains unproven.
A two-clinic Chiang Mai study of 150 MSM and transgender women found clinically significant depression in 5.3% of PrEP users and 13.3% of non-users. Mean depression was lower among PrEP users, while suicidal ideation occurred in 5.3% with no group difference.
An exploratory case-control study of 37 Thai adults with confirmed beta-lactam hypersensitivity identified HLA-DQA1*01:04 and HLA-DQA1*05:05 candidate signals after Bonferroni correction, with the latter stronger for immediate reactions. Small size, population controls and sensitivity-instability mean the findings are not ready for screening or drug avoidance.
Twenty male esports players were randomised to cup stacking three days weekly for four weeks or usual training. Post-intervention salivary alpha-amylase fell within the experimental group and differed significantly from controls.
Giant freshwater prawns received control diets or 10% and 20% fishmeal replacement with L. plantarum TISTR1284-fermented Leucaena for two weeks. Fermented diets increased immune markers and reduced post-A. hydrophila mortality by 26.14%, with normal intestinal morphology.
The systematic review identified 17 reports representing 15 randomised trials with 6,256 participants; 2,216 contributed to overweight subgroup analyses. The meta-analysis included 12 studies and 1,728 pregnant women with overweight. Interventions combined diet and physical activity, often with goal setting, self-monitoring and digital or remote follow-up.
A seven-country prospective cohort of 1,703 adults with HIV found Mycobacterium tuberculosis bloodstream infection predominantly among inpatients and associated it with higher 30-day mortality.
An evaluation of 1,838 stored sera from seven countries found that a second-generation Hcp1 antibody test had sensitivity ranging from 48% to 92%, with specificity varying by country and comparison group.
Thai researchersHasyanee Binmaeil · Thanakon Bunsong · Mary N. Burtnick · Paul J. Brett · Narisara Chantratita
Analysis of Thai national claims from 2015–2023 identified 60,916 paediatric hepatobiliary admissions. Admission rates were broadly stable and in-hospital mortality declined, while hepatic failure remained a high-risk condition.
An international expert statement spanning 22 countries reviews links among food systems, cardiometabolic health and the Sustainable Development Goals. It advocates plant-forward traditional diets rich in whole grains, legumes, vegetables, fruit, nuts and spices, with meat used sparingly.
The multicentre survey analysed 604 patients from 25 Thai hospitals between December 2023 and March 2024. SSRIs accounted for 70.2% of prescriptions, followed by TCAs at 13.9% and trazodone at 12.7%. The most common diagnoses were depressive disorders (55.0%), substance use disorders (15.2%) and psychotic disorders (13.7%). Clinicians cited limited availability (21.9%), reimbursement arrangements (36.3%) and patient finances (33.9%) as prescribing constraints.
Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.
3,510records
3,510 records
76IMPACT SIGNAL
Environmental Engineering
Removal, biodegradability, detoxification, and risk assessment of direct and indirect reclaimed water contaminated with 4-chloroaniline using ozonation and electro-peroxone processes
Comparative Assessment of Gill Cut and Water Perfusion Bleeding Methods on Freshness, Microbiological Stability, and Textural Properties of Asian Seabass (Lates calcarifer) Slices During Refrigerated Storage
Prince of Songkla University · Songkhla Rajabhat University
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Clinical Medicine
Agreement Between Echocardiography and Ultrasonic Cardiac Output Monitoring (USCOM) for Hemodynamic Assessment in Pediatric Patients: A Bland–Altman Analysis
Efficiency of Using a Fixed-Wrist Splint in Patients with Intra-Arterial Catheterization to Monitor Arterial Blood Pressure During a Surgical Intervention: A Pilot Study
New traveling wave solutions for the extended (3+1)-dimensional KdV-Calogero-Bogoyavlenskii-Schiff and the fourth-order nonlinear Ablowitz-Kaup-Newell-Segur water wave equations using efficient techniques
Suranaree University of Technology Hospital · Suranaree University of Technology · Chiang Mai University · Queen Sirikit National Institute of Child Health · Chiangmai Ram Hospital · National Science and Technology Development Agency · National Center for Genetic Engineering and Biotechnology
