Mortality effect of albumin fluid resuscitation in adults with septic shock: a systematic review and dual frequentist–bayesian meta-analysis of randomised trials
A systematic review and meta-analysis of seven randomised trials involving 3,273 adults found albumin-based resuscitation associated with a 10% relative reduction in mortality versus crystalloid at the longest follow-up. The confidence interval approached no effect and part of the evidence came from subgroups, leading the authors to rate certainty as low by GRADE.