Effect of Cosmetic Whitening Ingredients’ Lipophilicity on Melanocyte Cytotoxicity: A Systematic Review
A systematic review of 11 articles and 18 cosmetic-whitening ingredients derived MTT IC50 values and compared them with cLogP. The overall positive relationship was modest (R²=0.3263), and seven ingredients had IC50 below 50 micrograms/mL. Heterogeneous cell lines, media, exposure times and assays prevent this from being a human safety ranking.