THAI RESEARCH / GLOBAL SIGNAL

งานวิจัยไทย
ที่โลกกำลังจับตา

คัดผลงานใหม่จากแหล่งวิชาการสากล ตรวจสอบบทบาทนักวิจัยไทย และเล่าให้เห็นทั้งผลกระทบ ข้อจำกัด และแหล่งต้นทาง

3982RESEARCH WORKS

3982ผลงานในฐานข้อมูล3461อ่านฉบับเต็มได้476สาขาวิจัย

EDITOR'S SIGNALRotating editor's selection

Evidence of global relevance

Characteristics, management, and outcomes of segmental and subsegmental pulmonary embolism in ICU patients: A retrospective cohort study

Researchers reviewed 896 CT pulmonary angiograms from 804 ICU patients between January 2019 and June 2025. Pulmonary embolism was identified in 164 examinations, while 104 patients had segmental or subsegmental embolism without a more proximal clot. Anticoagulation was given to 96% of this group and 86% of treated patients received therapeutic dosing. At 90 days, bleeding occurred in 15%, major bleeding in 12%, recurrent venous thromboembolism in 7.8% and mortality in 24%.

Nuanprae Kitisin · Nattaya Raykateeraroj · Sikarin UpalaSiriraj Hospital · Mahidol University

Read the full feature →

IMPACT92/100

EDITORIAL DEEP DIVES

In-depth research analyses

Source-verified editorial analyses, ordered by latest publication date

1,027 analyses

clinical-medicine74IMPACT SIGNAL

Chikungunya virus infection: A comprehensive review of pathogenesis, diagnosis and management

Chikungunya fever (CHIKF), caused by the chikungunya virus (CHIKV), is an acute mosquito-borne viral disease that poses a rising global public health threat. To date, no specific antiviral therapies are available, and precise diagnosis is pivotal for optimal clinical management. This review systematically summarizes the latest evidence on CHIKV pathogenesis, diagnostic strategies, and clinical management based on English literature published between 2004 and 2025. Virus-host interactions dominate disease progression, including viral entry mediated by E1/E2 envelope proteins binding to host Mxra8 receptors and suppressed type I interferon responses via nsP2-mediated inhibition of the JAK-STAT pathway. The E1-A226V mutation greatly enhances viral transmissibility in Aedes albopictus, fueling the global spread of CHIKV. Clinically, persistent chronic arthropathy serves as the major long-term complication in 25%–40% of infected patients. Current diagnostic approaches consist of real-time RT-PCR as the early gold-standard test and serological antibody detection, whereas serological cross-reactivity with other arboviruses and inconsistent detection results frequently cause clinical misdiagnosis, and the confirmatory plaque reduction neutralization test (PRNT) is impractical for routine use. Clinical care for CHIKF remains predominantly supportive, relying on symptomatic treatment and close patient monitoring. Two FDA-approved vaccines have been licensed via accelerated approval based on immunogenicity surrogates, with solid clinical protective efficacy yet to be validated. This review highlights that in-depth elucidation of CHIKV pathogenic mechanisms, refinement of diagnostic accuracy, and development of targeted therapeutics are essential to improve the overall management…

Thai researchers

public-health73IMPACT SIGNAL

Loneliness, rumination, and adolescent psychological crisis in China: a pilot moderated mediation study

Background Adolescent psychological crisis—encompassing depressive disorder, anxiety disorder, and suicidal ideation—is a major public health challenge. One in five adolescents experiences a clinically significant mental health condition globally. Loneliness is a well-documented, modifiable risk factor for these outcomes. However, the exact cognitive-emotional pathways linking loneliness to acute psychological crisis remain unclear. This is particularly true in China, where rapid social change and intense academic pressure increasingly strain adolescent mental health. We do not yet fully understand how protective resources might buffer these specific pathways. Objectives and methods This pilot study tests a moderated mediation model based on the Evolutionary Theory of Loneliness and the stress-vulnerability framework. We investigate ruminative thinking as a cognitive-emotional mediator between loneliness and psychological crisis. We also test whether perceived social support and psychological resilience moderate distinct stages of this pathway. Based on a pilot sample of N = 312 Chinese adolescents (ages 12–18), we use structural equation modelling (SEM), confirmatory factor analysis (CFA), and Hayes’ PROCESS Macro (Model 14) with 5, 000 bootstrap replications. Two-wave longitudinal data ( n = 187, 8-week interval) were available for the depression outcome only; the anxiety and suicidal-ideation pathways were examined cross-sectionally. Results Loneliness is significantly associated with depressive symptoms (β = 0.43, p < 0.001), anxiety (β = 0.38, p < 0.001), and suicidal ideation (β = 0.27, p < 0.001). Ruminative thinking accounts for 40–46% of the total indirect association across all three outcomes. Social support buffers the transmission from loneliness to…

Thai researchers

multidisciplinary73IMPACT SIGNAL

Evidence for Step-Edge-Assisted Large Hole Borophene on Ni(111)

Due to its unique electronic properties, boron tends to form various multicenter bonds, enabling the construction of diverse two-dimensional borophene structures through modulation of the number and distribution of boron vacancies within a triangular lattice. In this study, we investigate a large-hole borophene model on heated Ni(111) substrates via molecular beam epitaxy under ultra-high-vacuum conditions. The complex atomic arrangement and electronic structures were investigated by scanning tunneling microscopy, low-energy electron diffraction, angle-resolved photoemission spectroscopy, and density functional theory calculations. Our results suggest that boron atoms are initially incorporated into the Ni surface and preferentially nucleated at step edges. The favorable geometric matching between the proposed structure and the Ni step-edge configuration contributes to the stabilization of the structure and facilitates its formation under the present growth conditions. These findings broaden the structural diversity of 2D borophene sheets and offer insights into the controlled synthesis of complex borophene architectures on metallic substrates.

Thai researchers

clinical-medicine73IMPACT SIGNAL

Geospatial determinants of diabetes risk in Thailand: socioeconomic and health service factors

Diabetes prevalence is increasing in Thailand, creating growing demands on the health system. Understanding the spatial distribution of diabetes risk and its association with socioeconomic and healthcare system factors among the diabetes risk population is critical for designing targeted prevention and intervention strategies. We examined the distribution of diabetes risk groups across provinces in Thailand with reference to the spatial association between economic, social and public health service factors based on data from the Ministry of Public Health's Health Data Center (HDC) for the year 2021. The dataset included 22,491,934 individuals across the 76 provinces as well as social, economic and public health services. The methods included Local Indicators of Spatial Association (LISA), Ordinary Least Squares (OLS), Spatial Lag Model (SLM) and Spatial Error Model (SEM). Explanatory variables included average night-time light intensity, average monthly income, hospital-to-population ratio and proportion of the population with health insurance. Major clusters of High-High (HH) diabetes risk were identified by LISA mainly located in the North of Thailand. In all models, the direction and significance of the associations were consistent (p

Thai researchers

clinical-medicine73IMPACT SIGNAL

Clear aligner therapy for early orthodontic treatment in children aged 6–13 years: A scoping review of clinical performance and evidence gaps

BACKGROUND: Clear aligner therapy has expanded substantially in mixed dentition, yet the boundaries of clinical predictability across indications, movement types, and growth stages remain incompletely defined. The aim of this review was to synthesize evidence on clear aligner therapy in mixed dentition, describe indication-specific performance patterns, and identify evidence gaps that limit clinical confidence. METHODS: This scoping review was reported in accordance with PRISMA-ScR. PubMed/MEDLINE, Embase, and Scopus were systematically searched for studies published from 2000 to 2025. Additional records were identified through Google Scholar and reference list searching. Randomized controlled trials, prospective and retrospective cohorts, and cross-sectional studies were eligible. Data were charted and synthesized descriptively. RESULTS: Fifty-nine studies were included (8 randomized controlled trials, 11 prospective cohorts, 38 retrospective cohorts, 2 cross-sectional), most involving children aged 7 to 12 years. Achieved transverse dentoalveolar expansion with clear aligners was lower than planned, particularly posteriorly and at gingival levels. Comparative studies suggested greater posterior and palatal changes with rapid maxillary expansion. Mandibular advancement aligners were associated with Class II sagittal improvement, with responses varying by skeletal maturity and dentoskeletal pattern. Evidence for incisor correction, molar movement, vertical outcomes, airway, oral health, patient-reported outcomes, and smile esthetics remained limited. CONCLUSIONS: Clear aligners in mixed dentition demonstrate indication-dependent predictability influenced by movement type, anatomical region, and growth stage. Clinical confidence remains limited by retrospective…

Thai researchers

public-health73IMPACT SIGNAL

The association between the American Heart Association Life’s Essential 8 and depression trajectories among postmenopausal women: findings from National Health and Nutrition Examination Survey 2011–2020

Depression is a psychological condition characterised by alterations in the mood and behaviour regulation in women experiencing 50% greater burden of depression than men (1) . Additionally, cardiovascular disease (CVD) is the leading cause of death in women globally while both CVD and depression can predict the incidence of each other reciprocally. Postmenopausal women particularly, during the menopause transition, are at increased risk of developing CVD and depression (2) . Life’s Essential 8 (LE8), is a recently developed cardiovascular health assessment index comprising eight health behaviours and factors: dietary quality, physical activity level, nicotine exposure, sleep health, body mass index, blood glucose, non-high-density lipoprotein cholesterol, and blood pressure (3) . It may be used to predict the risk of depression prevalence. This study investigated the association between LE8 and depression prevalence among postmenopausal women using the National Health and Nutrition Examination Survey (NHANES) 2011–2020 data. The LE8 score was calculated as the average of all eight components categorised into low (0–49), moderate (50–79), or high (80–100) cardiovascular health status (3) . Depression severity was assessed using the Patient Health Questionnaire-9 (PHQ-9) (4) . Complex survey-adjusted regression models were used. A total of 5472 postmenopausal women were included (mean age: 63.0 years), of whom 654 (12%) met the criteria for depression. The LE8 scores (mean ± SD) for those with and without depression were 53.2 ± 14.6 and 64.9 ± 14.7 (p < 0.001), respectively. Higher LE8 scores were significantly associated with lower odds of having depression (odds ratio [OR] per 10-point increase: 0.65, 95% CI: 0.60–0.72, p < 0.001). Moderate and high cardiovascular…

Thai researchers

engineering73IMPACT SIGNAL

Development of data-driven framework for the geotechnical behavior of xanthan gum-treated clay reinforced with polypropylene fibers

This study develops a robust data-driven modeling framework to predict the unconfined compressive strength (UCS) and stiffness (Go) of low-plasticity clay soils stabilized with Xanthan Gum (XG) and Polypropylene Fiber (PPF), aiming to advance sustainable geotechnical design. A total of 108 soil specimens were prepared with varying XG dosages and cured over different periods, and predictive models were constructed using a Decision Table algorithm optimized with six bio-inspired optimization techniques. Among these, the Firefly-optimized model consistently provided the highest accuracy, demonstrating reliable agreement between predicted and measured values. Sensitivity analysis identified XG dosage, curing time, and dry density as the most influential factors governing UCS and Go. These findings highlight the strong potential of the proposed machine learning framework to guide field engineers in optimizing mix design parameters for improved mechanical behavior of bio-treated soils, reducing reliance on time-consuming and costly laboratory tests while promoting environmentally sustainable foundation practices. The need for this study arises from the growing demand for green soil stabilization techniques that minimize the use of cement and lime while still ensuring reliable performance in construction. Its applicability extends to real-world geotechnical projects such as embankments, road subgrades, and shallow foundations, where predictive modeling can significantly streamline design decisions and improve long-term sustainability.

Thai researchers

multidisciplinary73IMPACT SIGNAL

Digital Triple-Code Model Game Intervention for Enhancing Mathematical Achievement and Working Memory in Children at Risk of Mathematical Difficulties

Children at risk of mathematical difficulties (MD) are increasingly prevalent worldwide. This study developed a digital game–based intervention grounded in the Triple-Code Model (TCM) and aligned with the standardized mathematics curriculum and learning indicators. The intervention design followed the ADDIE and digital game-based learning frameworks. Instruments were validated by experts and piloted with 45 children at risk of MD. Seventy primary school students aged 9–11 years were randomly assigned to experimental or control groups. Computerized tests of mathematical achievement, verbal working memory, and spatial working memory were administered. Results revealed significantly greater post-training improvements in the experimental group across all measures, with large effect sizes. The findings suggest that the digital TCM game effectively enhances mathematical performance and cognitive functioning, possibly through mechanisms involving positive emotion, goal-directed processing, and reduced cognitive load, supporting its potential as a supplementary educational tool for children at risk of MD.

Thai researchers

digital-health73IMPACT SIGNAL

When ethical frameworks meet reality: Unexamined gaps in the deployment of AI tools for mental health care

The use of artificial intelligence in mental health services is experiencing rapid development and is increasingly widespread across clinical, community, and digital service contexts (Bickman, 2020...

Thai researchers

multidisciplinary73IMPACT SIGNAL

Linking shelter conditions to health: A multisystem analysis of stress, metabolism, and fecal microbiota in dogs

Variations in space allocation and husbandry practices can significantly affect the health and welfare of long-term shelter dogs. This study compared adrenal, metabolic, and microbiological health indicators among dogs from three shelters in Thailand: Shelter A - low-density (20.3 m²/dog), adequate enclosure size (101.9 m²), and an enrichment program; Shelter B - medium-density (3.9 m²), large enclosures (150 m²); and Shelter C - high density (3.0 m²), one communal space (800 m²), and no enrichment. Fecal glucocorticoid metabolite (fGCM) concentrations, oxidative stress (malondialdehyde, MDA), metabolic parameters (glucose, insulin, fructosamine, lipid profiles), and fecal microbiota composition and diversity were measured and analyzed in relation to management factors. Dogs in Shelter A exhibited the lowest fGCM concentrations (207.41 ± 4.55 ng/g), normal metabolic profiles, and richer, more even fecal microbiota. In contrast, dogs in Shelter C, a temple-based facility with more crowding and limited space, exhibited higher fGCM (278.71 ± 10.44 ng/g) and fructosamine concentrations, reduced alpha diversity, and a highly skewed Firmicutes-to-Bacteroidota ratio, suggesting possible adrenal cortical and microbial dysbiosis. Shelter B presented intermediate values across most parameters and management inputs. These findings show that management practices, including space allocation and enrichment, can influence stress physiology, metabolic health, and fecal microbiota composition in long-term sheltered dogs.

Thai researchers

engineering73IMPACT SIGNAL

Forging Industry 4.0 Readiness: A Quasi‐Experimental Study on the Impact of Spreadsheet‐Integrated Automation in First‐Year Engineering Physics Labs

ABSTRACT The rapid global transformation catalyzed by Industry 4.0 fundamentally necessitates a reconstitution of the engineering skillset, particularly emphasizing digital tool proficiency, systematic problem formulation, and collaborative practice. A persistent and troubling skills gap remains, as traditional introductory physics laboratories, constrained by procedural compliance, routinely fail to cultivate these multidimensional professional competencies during the critical first‐year stage. This study addresses this pressing curricular deficit by rigorously evaluating a novel spreadsheet‐integrated automation framework (SIAF) designed for early curricular intervention. We utilized a quasi‐experimental mixed‐methods design involving 203 first‐year engineering students. Our methodology demonstrates technical depth by integrating ubiquitous spreadsheet software with low‐cost IoT microcontrollers (ESP32) for real‐time data processing and acquisition, thereby simulating authentic industrial workflows. Crucially, the study deployed a validated multi‐dimensional IRR, addressing a persistent methodological deficit in holistic competency assessment. Quantitative analysis confirmed the SIAF's robust efficacy, yielding statistically significant positive improvements across six competency domains. The most substantial gains were registered in domains essential for the digital workplace: spreadsheet skills ( d ≈ 0.65), technical skills ( d ≈ 0.45), and digital/automation literacy ( d ≈ 0.43). Qualitative data revealed that automation successfully reduced extraneous cognitive load, fostering systematic troubleshooting and a strong sense of digital fluency derived from self‐mastery. These results provide compelling empirical support for adopting this replicable, outcome‐based…

Thai researchers

multidisciplinary73IMPACT SIGNAL

Evolving Pathways of Departure and Return in Rural Thailand

ABSTRACT This paper draws on a forty‐year longitudinal (1982–2022) village study of Thailand to reflect on how circulation persists, but in new ways. We trace evolving migration flows over a period during which Thailand progressed from low‐income to upper‐middle‐income status, and Non Tae and Tha Song Korn from semi‐subsistence rice‐growing communities to increasingly prosperous settlements with multi‐stranded livelihoods. Villagers accumulated considerable educational capital and left the villages in growing numbers to find work in other places and sectors. They also, however, in large part also returned, raising questions about linear and one‐directional theories of agrarian and mobility transition. It is argued that departure and return continue to be co‐produced in response to conditions in the villages and the wider Thai economy. Circulation is a central element in understanding Thailand's truncated agrarian transition, and vice vera.

Thai researchers

BIBLIOGRAPHIC RESEARCH WATCHLIST

Bibliographic research records

Thailand-affiliated bibliographic records. These are not full analyses; they are ordered by Impact Signal and should be verified against the original source.

2,955records

2,955 records

85IMPACT SIGNAL

Multidisciplinary30 Sep 2026

Effectiveness of an Integrated Activity-Based and Tele-Monitoring Intervention on Mental Health Literacy and Resilience among Urban Older Adults in Thailand: A Quasi-Experimental Study

Journal of Health Research

Thailand-affiliated authors: Khunatpakorn Makkabphalanon · Pramote Thangkratok · Jutamast Wongjan · Natchaya Palacheewa
Institutions: Praboromarajchanok Institute Ministry of Public Health · Boromarajonani College of Nursing, Nakhon Ratchasima · Srisavarindhira Thai Red Cross Institute of Nursing

85IMPACT SIGNAL

Multidisciplinary30 Sep 2026

Valorization of polyphenol-rich extracts from Oroxylum indicum (L.) kurz outer stem bark as sustainable textile colourants: Comparison concerns selected GOTS 7.0 colour fastness criteria on effects of six mordants and pre-, meta- and post-mordanting techniques on dyeing properties

Frontiers in Engineering Innovation Research

Thailand-affiliated authors: Siripan Metanawin · Apichart Sonthisombat · Mahamasuhaimi Masae · Sumonman Niamlang · Jantana Sutdaen · Pannarai Rug-ngarn · Orathai Tangsirinaruenart · Tanapak Metanawin · Sarunya Puakpong
Institutions: Rajamangala University of Technology · Rajamangala University of Technology Srivijaya · King Mongkut's University of Technology North Bangkok · Kasetsart University

85IMPACT SIGNAL

Multidisciplinary30 Sep 2026

Role of Legislation in Occupational Disease Prevention: A Case of Chronic Silicosis with Progressive Massive Fibrosis

THE BANGKOK MEDICAL JOURNAL

Thailand-affiliated authors: Thammarath Thiamsuk · Supakorn Chansaengpetch · Tirathat Virojskulchai · Ekanut Jamsai · Sitthiphon Bunman · Narongpon Dumavibhat
Institutions: Siriraj Hospital · Mahidol University · Chulalongkorn University · Thammasat University

85IMPACT SIGNAL

Environmental Engineering30 Sep 2026

Macroevolutionary dynamics and predictors of tropical rain forest plant diversity

Science Advances

Thailand-affiliated authors: Pasakorn Bunchalee · Tanawat Chaowasku · Anissara Damthongdee · Charan Leeratiwong
Institutions: Mahasarakham University · Chiang Mai University · Prince of Songkla University

85IMPACT SIGNAL

Multidisciplinary30 Sep 2026